邻氨基苯甲酸
乙酰苯胺
组合化学
酮
溴化物
化学
芳基
有机化学
烷基
作者
Aita Saikiran,Swarnayu Banik,Chidrawar Ajay,P. R. Deepthi,Balasubramanian Gopalan,B. V. Subba Reddy
标识
DOI:10.1002/slct.202302076
摘要
Abstract An efficient and scalable process has been developed for the synthesis of anthranilic diamide insecticide i. e. chlorantraniliprole. The crucial step in this approach is the TiCl 4 ‐mediated aza‐Fries rearrangement of aryl acetanilide to ortho ‐aminoaryl ketone. Another key step is the nucleophilic substitution of tosylate into the corresponding bromide using NaBr in the presence of TBAB. All the steps in this synthesis are carried out effectively on a gram scale with excellent yields.
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