类有机物
芯片上器官
生物医学
纳米技术
多细胞生物
计算机科学
微流控
精密医学
实验室晶片
范围(计算机科学)
材料科学
生物信息学
化学
生物
医学
神经科学
病理
基因
生物化学
程序设计语言
作者
Zhangjie Li,Qinyu Li,Chenyang Zhou,Kangyi Lu,Yijun Liu,Lian Xuan,Xiaolin Wang
出处
期刊:Biomicrofluidics
[American Institute of Physics]
日期:2023-09-01
卷期号:17 (5)
摘要
In vitro organoid models, typically defined as 3D multicellular aggregates, have been extensively used as a promising tool in drug screening, disease progression research, and precision medicine. Combined with advanced microfluidics technique, organoid-on-a-chip can flexibly replicate in vivo organs within the biomimetic physiological microenvironment by accurately regulating different parameters, such as fluid conditions and concentration gradients of biochemical factors. Since engineered organ reconstruction has opened a new paradigm in biomedicine, innovative approaches are increasingly required in micro-nano fabrication, tissue construction, and development of pharmaceutical products. In this Perspective review, the advantages and characteristics of organoid-on-a-chip are first introduced. Challenges in current organoid culture, extracellular matrix building, and device manufacturing techniques are subsequently demonstrated, followed by potential alternative approaches, respectively. The future directions and emerging application scenarios of organoid-on-a-chip are finally prospected to further satisfy the clinical demands.
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