Cu(ii)-catalyzed cross coupling cyanomethylation of tetrahydroisoquinolines with α-bromoalkylnitrile

Herein, we present a Cu( ii )-mediated C–C reaction with α-haloacetonitrile derivatives and aryl tetrahydroisoquinolines via a coupling of C(sp 3 )–Br and C(sp 3 )–H bonds, yielding cyanomethylated tetrahydroisoquinolines.