Nanomaterial-based chemiluminescence systems for tracing of reactive oxygen species in biosensors

Reactive oxygen species (ROS), well-known as the highly reactive small molecules, play an important role in physiological and pathogenic events. Therefore, the detection of ROS receives a great deal of interest. With the rapid development of nanotechnology and nanomaterials, the nanomaterial-based chemiluminescence (CL) biosensors with good selectivity and high sensitivity have risen for tracing of the ROS. The nanomaterial-based CL biosensors not only provide the quantitative detection of ROS, but also the real-time generation dynamic of ROS. In this review, we summarized the applications of nanomaterial-based CL biosensors for tracing of ROS in recent years. Furthermore, we focused on the approaches for the design of nanomaterial-based CL biosensors for tracing of ROS, including the selection of nanomaterials and the basic mechanism for selective detection of ROS. Finally, we provided our thinking and predictions on exploring novel nanomaterial-based CL platforms. This review may open viable opportunities and inspirations for the researchers in analytical chemistry and material science to design new strategies for ROS tracing in a variety of biological environments.