医学
抗生素
肝硬化
荟萃分析
观察研究
上消化道出血
随机对照试验
科克伦图书馆
子群分析
相对风险
内科学
梅德林
胃肠道出血
置信区间
内窥镜检查
微生物学
政治学
法学
生物
作者
Connor Prosty,Dean Noutsios,Laurie-Rose Dubé,Rachel Baden,Kusha Davar,Sarah Freling,Taft Bhuket,Hal F. Yee,Brad Spellberg,Emily G. McDonald,Todd C. Lee
标识
DOI:10.1001/jamainternmed.2025.3832
摘要
The findings of this systematic review and bayesian meta-analysis do not support the purported mortality benefit driving guideline recommendations for antibiotic prophylaxis in patients with cirrhosis and upper gastrointestinal bleeds. Although prophylaxis reduced reported infections, methodological concerns regarding infection definitions introduced high risk of bias. Higher-quality RCTs are needed to determine the benefit and optimal duration of antibiotic prophylaxis in the modern era of advanced interventions. Until these studies are available, clinicians should be aware that the current guideline recommendations are not based on high-quality evidence.
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