Visible‐Light‐Promoted C─H Alkylation of Azauracils Via a Site‐Selective 1,5‐Hydrogen Atom Transfer‐Induced Cross‐Dehydrogenative Coupling

Abstract A visible‐light‐induced alkylation of azauracils was developed via the site‐selective 1,5‐hydrogen atom transfer of hydroxamic acid derivatives. The cross‐dehydrogenative coupling reaction between C(sp 2 )─H bond in azauracils and the γ‐C(sp 3 )─H bond in hydroxamic acid derivatives was involved. Notable features of this protocol include its mild and metal‐free reaction conditions, significant atom/step efficiency, broad substrate scope, and its application in the late‐stage modification of pharmaceutical compounds.