化学
细胞凋亡
MCF-7型
癌细胞
程序性细胞死亡
细胞培养
癌症
癌症研究
活性氧
药理学
生物化学
生物
医学
内科学
遗传学
人体乳房
作者
Acácio S. de Souza,D. S. Dias,Ruan Stevan de Almeida Ribeiro,Dora C. S. Costa,Matheus G. de Moraes,David R. Pinho,Maria E. G. Masset,L. Marins,S. Valle,Cristiano Carvalho,Gustavo Senra Gonçalves de Carvalho,Angélica Lauria do Nascimento Mello,Mauro Sola‐Penna,Marcos V. Palmeira-Mello,Raissa Alves da Conceição,Carlos Rangel Rodrigues,Alessandra Mendonça Teles de Souza,Luana da S. M. Forezi,Patrícia Zancan,Vı́tor F. Ferreira,Fernando de Carvalho da Silva
标识
DOI:10.1016/j.bmc.2024.117671
摘要
The search for novel anticancer drugs is essential to expand treatment options, overcome drug resistance, reduce toxicity, promote innovation, and tackle the economic impact. The importance of these studies lies in their contribution to advancing cancer research and enhancing patient outcomes in the battle against cancer. Here, we developed new asymmetric hybrids containing two different naphthoquinones linked by a 1,2,3-1H-triazole nucleus, which are potential new drugs for cancer treatment. The antitumor activity of the novel compounds was tested using the breast cancer cell lines MCF-7 and MDA-MB-231, using the non-cancer cell line MCF10A as control. Our results showed that two out of twenty-two substances tested presented potential antitumor activity against the breast cancer cell lines. These potential drugs, named here 12g and 12h were effective in reducing cell viability and promoting cell death of the tumor cell lines, exhibiting minimal effects on the control cell line. The mechanism of action of the novel drugs was assessed revealing that both drugs increased reactive oxygen species production with consequent activation of the AMPK pathway. Therefore, we concluded that 12g and 12h are novel AMPK activators presenting selective antitumor effects.
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