聚吡咯
材料科学
自愈水凝胶
聚苯胺
药物输送
导电体
导电聚合物
生物医学工程
壳聚糖
纳米技术
化学工程
聚合物
高分子化学
复合材料
聚合
医学
工程类
作者
Lei Wan,Ning Xu,Xiaodong Wu,Ming Liu,Yongxin Liu,Zhao Jun,Ting Zhang,J. W. Zhao,Yi Zhou,Qingqing Xie,Ying‐Li Hu,Xiaoqing Jiang,Chen Tang,Yuping Quan,Shareen Shafique,Ye Tian,X. Zhang,Yuejun Zhang,Kun Zhou,Jiangbei Cao,Jiawen Jian,Yuheng Wang
标识
DOI:10.1016/j.ijbiomac.2023.128520
摘要
In this study, we developed an enhanced heterogeneous interface intelligent conductive hydrogel NH3 sensor for individualized treatment of infected wounds. The sensor achieved monitoring, self-diagnosis, and adaptive gear adjustment functions. The PPY@PDA/PANI(3/6) sensor had a minimum NH3 detection concentration of 50 ppb and a response value of 2.94 %. It also had a theoretical detection limit of 49 ppt for infected wound gas. The sensor exhibited a fast response time of 23.2 s and a recovery time of 42.9 s. Tobramycin (TOB) was encapsulated in a self-healing QCS/OD hydrogel formed by quaternized chitosan (QCS) and oxidized dextran (OD), followed by the addition of polydopamine-coated polypyrrole nanowires (PPY@PDA) and polyaniline (PANI) to prepare electrically conductive drug-loaded PPY@PDA/PANI hydrogels. The drug-loaded PPY@PDA/PANI hydrogel was combined with a PANI/PVDF membrane to form an enhanced heterogeneous interfacial PPY@PDA/PANI/PVDF-based sensor, which could adaptively learn the individual wound ammonia response and adjust the speed of drug release from the PPY@PDA/PANI hydrogel with electrical stimulation. Drug release and animal studies demonstrated the efficacy of the PPY@PDA/PANI hydrogel in inhibiting infection and accelerating wound healing. In conclusion, the gas-sensitive conductive hydrogel sensing system is expected to enable intelligent drug delivery and provide personalized treatment for complex wound management.
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