The Significance of Sizes

In this issue of CHEST, Samanta et al1 present their investigation into the adoption of protective ventilation in a diverse and well-sized patient population. Their analysis of data from over 12,000 patients sheds light on the insufficient utilization of low tidal volume ventilation (LTVV) in critically ill, invasively ventilated patients in North America and the United Kingdom. Notably, among the patients in their cohort, those exposed to excessively high tidal volume (VT) experienced the highest mortality rates.