Prognostic utility of procalcitonin and lactate clearance for in-hospital mortality in sepsis

Lactate clearance with 10% cutoff is a better predictor of in-hospital mortality in patients presenting to the ED with sepsis or septic shock compared to PCTc. An optimal PCTc cutoff of 23.1% was identified; however, it did not reach statistical significance for survival. Future prospective studies are needed to better define optimal biomarker cutoffs and compare their predictive accuracy for in-hospital mortality.