Ramelteon Ameliorates Isoflurane-Induced Hyperactivity and Social-Recognition Impairment in Aged Mice

Isoflurane anesthesia combined with abdominal surgery was associated with prolonged hyperactivity and impaired social recognition, although other cognitive domains such as working memory appeared to remain unaffected. Ramelteon appeared to alleviate these behavioral and neuroinflammatory changes, suggesting its potential for preventing certain postoperative neurobehavioral alterations.