Adipocyte‐specific deletion of the mineralocorticoid receptor improves glucose homeostasis and associates with FGF21 ‐adiponectin signalling in obese male mice

Deletion of the adipocyte MR activates the FGF-21/β-klotho/adiponectin axis in obese male mice only. Thus, these data indicate that the dysfunctional FGF-21/β-klotho/adiponectin axis is associated with impaired glucose handling in a sex-specific manner.