Yangxinshi tablet protects against myocardial injury and increases skeletal muscle exercise capacity by regulating mitochondrial bioenergetics

This study revealed that YXST improved cardiac function and exercise tolerance in I/R mice, particularly we found that YXST could directly enhance the exercise capacity of mice under normal condition. Mechanismly, YXST significantly regulated mitochondrial biogenesis, oxidative phosphorylation and myokine production in vivo and in vitro. Our findings provide novel mechanistic insights and pharmacological basis for the application of YXST against coronary heart disease and skeletal muscle injury.