EZH2型
表观遗传学
衰老
多发性骨髓瘤
癌症研究
甲基转移酶
生物
细胞生物学
增强子
化学
甲基化
遗传学
免疫学
转录因子
DNA
基因
作者
Shushan Guo,Qiongwei Tang,Xuejie Gao,Liangning Hu,Ke Hu,Hui Zhang,Qikai Zhang,Yue Lai,Yujie Liu,Zhuning Wang,Shuaikang Chang,Yifei Zhang,Huifang Hu,Dong An,Yu Peng,Haiyan Cai,Jumei Shi
摘要
Epigenetic modifications play an important role in cellular senescence, and enhancer of zeste homolog 2 (EZH2) is a key methyltransferase involved in epigenetic remodeling in multiple myeloma (MM) cells. We have previously demonstrated that GSK126, a specific EZH2 inhibitor, exhibits anti-MM therapeutic efficacy and safety
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(2025-6-4)
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