记忆B细胞
抗原
生物
抗体
幼稚B细胞
B细胞
病毒学
记忆T细胞
佐剂
免疫系统
接种疫苗
T细胞
免疫学
抗原提呈细胞
作者
L. A. Grigoryan,Yupeng Feng,Lorenza Bellusci,Lilin Lai,Bushra Wali,Madison Ellis,Meng Yuan,Prabhu S. Arunachalam,Mary Y. Hu,Sangeeta Kowli,Sheena Gupta,Sofia Maysel-Auslender,Holden T. Maecker,Hady Samaha,Nadine Rouphael,Ian A. Wilson,Alberto Moreno,Mehul S. Suthar,Surender Khurana,Stéphane Pillet,Nathalie Charland,Brian J. Ward,Bali Pulendran
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2024-04-05
卷期号:9 (94)
标识
DOI:10.1126/sciimmunol.adi8039
摘要
Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is due to the generation of antigen-specific B cell clones with distinct specificities or the maturation of memory B cell clones that produce broadly cross-reactive antibodies is unknown. Here, we longitudinally analyzed immune responses in healthy adults after two-dose vaccination with either a virus-like particle COVID-19 vaccine (CoVLP), CoVLP adjuvanted with AS03 (CoVLP+AS03), or a messenger RNA vaccination (mRNA-1273). CoVLP+AS03 enhanced the magnitude and durability of circulating antibodies and antigen-specific CD4 + T cell and memory B cell responses. Antigen-specific CD4 + T cells in the CoVLP+AS03 group at day 42 correlated with antigen-specific memory B cells at 6 months. CoVLP+AS03 induced memory B cell responses, which accumulated somatic hypermutations over 6 months, resulting in enhanced neutralization breadth of monoclonal antibodies. Furthermore, the fraction of broadly neutralizing antibodies encoded by memory B cells increased between day 42 and 6 months. These results indicate that AS03 enhances the antigenic breadth of B cell memory at the clonal level and induces progressive maturation of the B cell response.
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