Crosstalk between TPC2 and IP3R regulates Ca2+ signals

Calcium (Ca²⁺) plays a pivotal role in cellular signal transmission by triggering downstream signaling in response to an increase in the cytosolic Ca²⁺ concentration. Intracellular organelles serve as Ca²⁺ stores that induce differently shaped Ca²⁺ signals. We discuss a study by Yuan et al. that investigated the interplay between the lysosomal two-pore channel 2 (TPC2) and endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptors (IP₃Rs).