Precise organization of metal nanoparticles on DNA origami template

Nanoscale assemblies of metal nanoparticles in one dimension (1D) to three dimensions (3D) can exhibit novel phenomena that are not observed in the amorphous state. Bottom-up assembly technique is expected to overcome the resolution limit of top-down method and casts a new light on the nanofabrication field. DNA origami, which is mainly used to construct discrete and addressable nanostructures, can be utilized to assemble functional colloidal nanoparticles into delicate geometries with interesting properties. This review aims to summarize the methods that use DNA origami structures as templates to precisely organize metal nanoparticles, such as gold nanospheres (AuNSs) gold nanorods (AuNRs) and silver nanoparticles (AgNPs). The potential applications and the perspective are also discussed.