和男人发生性关系的男人
基因型
人口学
分子流行病学
病毒学
传输(电信)
人类免疫缺陷病毒(HIV)
系统发育树
流行病学
人口
医学
生物
遗传学
内科学
基因
社会学
工程类
梅毒
电气工程
作者
Yongkang Yin,Ying Zhou,Jing Lu,Xiaoyan Liu,Lingen Shi,Gengfeng Fu,Xiping Huan,Shenghao Fang,Yuxiang Liu,Wang Bei,Jian-ping Ding
标识
DOI:10.1089/aid.2020.0165
摘要
Investigation of disease and intervention in populations of men having sex with men (MSM) has garnered attention globally, a primary reason being the rapid increase in the prevalence of human immunodeficiency virus (HIV)-1 among MSM. The purpose of this study was to understand the current HIV-1 molecular characteristics and characterize HIV-1 transmission networks in the MSM population. Nine hundred and fourteen newly diagnosed HIV-positive MSM were included in this study. The HIV-1 pol gene region was amplified and sequenced. A maximum likelihood phylogenetic tree was constructed, and transmission clusters were identified using 1.5% distance and 0.9 bootstrap values. In total, 767 sequences were successfully obtained, with CRF01_AE being the major genotype (43.3%, 332/767), followed by CRF07_BC (31.3%, 240/767), CRF67_01B (7.2%, 55/767), and URF (6.4%, 49/767). The transmitted HIV drug resistance rate was 4.0% (31/767), and the most common mutations were E138G (n = 4) and G190A (n = 4). A total of 182 (23.7%) sequences were included in the HIV-1 transmission networks, forming 79 clusters. Four clusters were identified as fast-growing, and the proportion of young MSM was higher than that of non-MSM (51.6% vs. 31.8%). The genetic diversity of HIV-1 in Jiangsu was complex, and cross-region transmission might exist for CRF67_01B. Transmission among young MSM within networks was greater than the other age groups; thus, they could be essential in the control of the HIV epidemic in Jiangsu. This study was approved by the ethical review board of the National Center for AIDS/STD Control and Prevention (Project No. X140617334).
科研通智能强力驱动
Strongly Powered by AbleSci AI