16S核糖体RNA
生物
微生物学
牙菌斑
微生物群
核糖体RNA
齿面
唾液
细菌
基因
遗传学
牙科
医学
生物化学
作者
Yukari Ihara,Toru Takeshita,Shinya Kageyama,Rie Matsumi,Mikari Asakawa,Yukie Shibata,Yuki Sugiura,Kunio Ishikawa,Ichiro Takahashi,Yoshihisa Yamashita
出处
期刊:MSystems
[American Society for Microbiology]
日期:2019-10-29
卷期号:4 (5)
被引量:23
标识
DOI:10.1128/msystems.00360-19
摘要
Selective attachment of salivary bacteria to the tooth surface is an initial and repetitive phase in dental plaque development. We employed full-length 16S rRNA gene sequence analysis with a high taxonomic resolution using a third-generation sequencer, PacBio Sequel, to determine the bacterial composition during early plaque formation in 74 young adults accurately and in detail. The results revealed 21 bacterial taxa primarily involved in early plaque formation on hydroxyapatite disks in young adults, which include several streptococcal species as well as nonstreptococcal species, such as Neisseria sicca / N . flava / N . mucosa and Rothia dentocariosa . Given that no notable variations in the microbiota composition were associated with the dental caries status, the maturation process, rather than the specific bacterial species that are the initial colonizers, is likely to play an important role in the development of dysbiotic microbiota associated with dental caries.
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