聚乙烯醇
羧甲基纤维素
纳米纤维
纳米复合材料
戊二醛
材料科学
细菌纤维素
静电纺丝
化学工程
傅里叶变换红外光谱
纤维素
化学
聚合物
纳米技术
复合材料
有机化学
钠
冶金
工程类
作者
Behzad Darbasizadeh,Yousef Fatahi,Bahareh Feyzi-barnaji,Mahshid Arabi,Hamidreza Motasadizadeh,Hassan Farhadnejad,Fatemeh Moraffah,Rafael Luque
标识
DOI:10.1016/j.ijbiomac.2019.09.060
摘要
Recently, nanocomposite nanofibers have been extensively used for biomedical applications. It is expected that simultaneous incorporation of antibiotic drugs and ZnO nanoparticles into nanofiber resulted in providing the synergistic anti-bacterial effect. The main aim of the present study is to fabricate polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC)-ZnO nanocomposite fibrous mats containing erythromycin (EM) drug and crosslink them using 2% glutaraldehyde vapor and 3% AlCl3 alcoholic solution. The fabricated nanofibers characterized via TGA, FTIR, TEM, and SEM, indicating that the addition of ZnO nanoparticles and EM molecules into the fabricated nanofibers resulted in changing their average diameter. Their anti-bacterial activity was studied against S. aureus and E. coli and found that PVA-CMC/ZnO-EM nanofibers show excellent antimicrobial activity. In-vitro release profile showed that EM release from PVA-CMC/ZnO-EM nanofibers was slowly increased. Sustained drug release profile and excellent anti-bacterial activity of PVA-CMC/ZnO-EM nanofiber indicated that it was an ideal biomaterial for wound dressings.
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