衣壳
病毒性心肌炎
柯萨奇病毒
病毒学
病毒生命周期
心肌炎
病毒复制
蛋白酵素
病毒
病毒进入
核酸
生物
计算生物学
肠道病毒
医学
遗传学
生物化学
酶
心脏病学
作者
Madhu Khanna,Anju Gautam,Roopali Rajput,Latika Sharma
标识
DOI:10.2174/1568026620666200129094516
摘要
Coxsackievirus B3 (CVB3), a member of the Picornaviridae family, is considered to be one of the most important infectious agents to cause virus-induced myocarditis. Despite improvements in studying viral pathology, structure and molecular biology, as well as diagnosis of this disease, there is still no virus-specific drug in clinical use. Structural and nonstructural proteins produced during the coxsackievirus life cycle have been identified as potential targets for blocking viral replication at the step of attachment, entry, uncoating, RNA and protein synthesis by synthetic or natural compounds. Moreover, WIN (for Winthrop) compounds and application of nucleic-acid based strategies were shown to target viral capsid, entry and viral proteases, but have not reached to the clinical trials as a successful antiviral agent. There is an urgent need for diverse molecular libraries for phenotype-selective and high-throughput screening.
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