免疫系统
生物
癌症
细胞因子
转化生长因子
癌细胞
癌症研究
CD8型
免疫
细胞生物学
免疫学
遗传学
作者
Ming Liu,Fengshen Kuo,Kristelle J. Capistrano,Davina Kang,Briana G. Nixon,Shi Wei,Chun Chou,H. Mytrang,Efstathios G. Stamatiades,Shengyu Gao,Shun Li,Yingbei Chen,James J. Hsieh,A. Ari Hakimi,Ichiro Taniuchi,Timothy A. Chan,Ming O. Li
出处
期刊:Nature
[Springer Nature]
日期:2020-10-21
卷期号:587 (7832): 115-120
被引量:138
标识
DOI:10.1038/s41586-020-2836-1
摘要
The immune system uses two distinct defence strategies against infections: microbe-directed pathogen destruction characterized by type 1 immunity1, and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue repair2. Similar to infectious diseases, cancer progresses with self-propagating cancer cells inflicting host-tissue damage. The immunological mechanisms of cancer cell destruction are well defined3-5, but whether immune-mediated cancer cell containment can be induced remains poorly understood. Here we show that depletion of transforming growth factor-β receptor 2 (TGFBR2) in CD4+ T cells, but not CD8+ T cells, halts cancer progression as a result of tissue healing and remodelling of the blood vasculature, causing cancer cell hypoxia and death in distant avascular regions. Notably, the host-directed protective response is dependent on the T helper 2 cytokine interleukin-4 (IL-4), but not the T helper 1 cytokine interferon-γ (IFN-γ). Thus, type 2 immunity can be mobilized as an effective tissue-level defence mechanism against cancer.
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