Nanosol SERS quantitative analytical method: A review

As an important analysis technology, SERS has the characteristics of fast, sensitive, informative and highly selective. The sensitivity and reproducibility are highly dependent on the properties of SERS substrate, thus it is a study hotspot in SERS quantitative. Although solid phase substrates are widely and early utilized in SERS detection, there are some problems in reproducibility and accuracy and complicated drying process. With development of nanotechnology, facile, highly SERS active, stable and reproducible nanosol substrates were prepared that overcome the problems and fills the gap in this area and expands the application field of SERS quantitative analysis. Using nanoenzyme and bioenzyme catalysis of nanoparticle and molecular reactions to amplify SERS signal, and aptamer to improve the selectivity, some highly sensitive and selective nanosol SERS quantitative analysis methods have been developed with good accuracy. Combining with the work of our group, this paper summarizes the progress of SERS quantitative analysis.