Did the Brain and Oral Microbiota Talk to Each Other? A Review of the Literature

医学 口腔微生物群 痴呆 自闭症 微生物群 心理健康 双相情感障碍 精神科 疾病 自闭症谱系障碍 梅德林 认知 生物信息学 病理 法学 政治学 生物
作者
Yoann Maitre,Pierre Micheneau,Alexis Delpierre,Rachid Mahalli,Marie Guérin,Gilles Amador,Frédéric Denis
出处
期刊:Journal of Clinical Medicine [Multidisciplinary Digital Publishing Institute]
卷期号:9 (12): 3876-3876 被引量:49
标识
DOI:10.3390/jcm9123876
摘要

This systematic review aims to investigate the role of the oral microbiome in the pathophysiology of mental health disorders and to appraise the methodological quality of research of the oral–brain axis which is a growing interest area. The PRISMA guideline was adopted, to carry out an electronic search through the MEDLINE database, to identify studies that have explored the role of the oral microbiome in the pathophysiology of mental health disorders published from 2000 up to June 2020. The search resulted in 140 records; after exclusions, a total of 22 papers were included in the present review. In accordance with the role of the oral microbiome in the pathophysiology of mental disorders, four mental disorders were identified: Alzheimer’s disease, dementia, and cognitive disorders; autism spectrum disorder; Down’s syndrome and mental retardation; and Bipolar disorders. Studies argue for correlations between oral microbiota and Alzheimer’s disease, autism spectrum disorders, Down’s syndrome, and bipolar disorders. This field is still under-studied, and studies are needed to clarify the biological links and interconnections between the oral microbiota and the pathophysiology of all mental health disorders. Researchers should focus their efforts to develop research on the oral–brain axis in the future.
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