光敏剂
纳米载体
光热治疗
阿霉素
化学
光动力疗法
体内
两亲性
生物物理学
活性氧
胶束
荧光寿命成像显微镜
药物输送
共聚物
荧光
纳米技术
材料科学
生物化学
化疗
光化学
水溶液
聚合物
有机化学
量子力学
生物技术
外科
物理
生物
医学
作者
Chao Wang,Baoxuan Huang,Guoliang Yang,Yingjie Ouyang,Jia Tian,Weian Zhang
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2019-10-08
卷期号:20 (11): 4218-4229
被引量:33
标识
DOI:10.1021/acs.biomac.9b01123
摘要
Imaging-guided chemo-phototherapy based on multifunctional nanocarriers has emerged as a promising and high-efficient cancer treatment because of the inevitable limitations of single therapy. Herein, a near-infrared (NIR) light-activated degradable polymeric nanoplatform was fabricated for chemo-phototherapy. An NIR photosensitizer, IR780, and a chemotherapeutic drug, doxorubicin (DOX), were efficiently coloaded within a reactive oxygen species (ROS)-sensitive polymeric micelle based on an amphiphilic copolymer with degradable thioketal (TK) linkages. The obtained spherical nanoparticles (denoted as (IR780/DOX)@PTK) exhibited a notable photodynamic and photothermal effect upon NIR light exposure. Furthermore, due to the rapid cleavage of TK linkers induced by ROS generated from NIR-activated IR780, (IR780/DOX)@PTK also showed an NIR light-induced degradable feature, which can be used for light-triggered tumor-specific drug release and lead to ignorable systematic toxicity after biodegradation and drug delivery. Under the guidance of NIR fluorescence and photothermal dual modal imaging, (IR780/DOX)@PTK exhibited excellent tumor accumulation after intravenously injection into 4T1-tumor-bearing mice. As verified in both in vitro and in vivo study, (IR780/DOX)@PTK presented a significant tumor suppression effect by synergistic chemo-phototherapy.
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