过氧亚硝酸盐
活性氧
生物物理学
一氧化氮
化学
光动力疗法
光化学
光敏剂
纳米技术
纳米颗粒
材料科学
超氧化物
纳米囊
有机化学
酶
生物
生物化学
作者
Zhixiong Wang,Meixiao Zhan,Weijie Li,Chengyan Chu,Da Xing,Siyu Lu,Xianglong Hu
标识
DOI:10.1002/anie.202013301
摘要
Abstract Photoacoustic (PA) technology can transform light energy into acoustic wave, which can be used for either imaging or therapy that depends on the power density of pulsed laser. Here, we report photosensitizer‐free polymeric nanocapsules loaded with nitric oxide (NO) donors, namely NO‐NCPs, formulated from NIR light‐absorbable amphiphilic polymers and a NO‐releasing donor, DETA NONOate. Controlled NO release and nanocapsule dissociation are achieved in acidic lysosomes of cancer cells. More importantly, upon pulsed laser irradiation, the PA cavitation can excite water to generate significant reactive oxygen species (ROS) such as superoxide radical (O 2 .− ), which further spontaneously reacts with the in situ released NO to burst highly cytotoxic peroxynitrite (ONOO − ) in cancer cells. The resultant ONOO − generation greatly promotes mitochondrial damage and DNA fragmentation to initiate programmed cancer cell death. Apart from PA imaging, PA cavitation can intrinsically amplify reactive species via photosensitization‐free materials for promising disease theranostics.
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