粘蛋白
粘液
生物
微生物学
益生菌
蛋白酶
乳酸菌
粘蛋白2
蛋白酵素
细菌
肠粘膜
双歧杆菌
分泌物
作者
Durai B. Subramani,Malin Johansson,Gunnar Dahlén,Gunnar C. Hansson
出处
期刊:Beneficial Microbes
[Wageningen Academic Publishers]
日期:2010-11-01
卷期号:1 (4): 343-350
被引量:29
摘要
The colon epithelium is covered by two layers of mucus built around the MUC2 mucin. An inner dense and attached mucus layer does not allow bacteria to penetrate, thus keeping the epithelial cell surface free from bacteria. An outer loose mucus layer is the habitat for the commensal bacterial microbiota. The inner mucus layer is renewed from the epithelial side and gets converted into the outer layer due to proteolytic cleavages by host proteases. We have now analysed if potential probiotic bacteria, namely Lactobacillus brevis, Lactobacillus plantarum, Lactobacillus bulgaricus and Bifidobacterium lactis, can secrete protease that cleaves the MUC2 mucin. We found that none of the potential probiotic bacteria Lactobacillus and Bifidobacterium could cleave the MUC2 core protein in the form of recombinant MUC2 N and C-termini although they secreted active proteases. This was in contrast to crude mixtures of oral and faecal bacteria that cleaved the MUC2 mucin. This observation further supports the view that these potential probiotic bacteria are of no harm to the host, as these bacteria cannot disrupt the mucin organised mucus as long as they are covered by glycans.
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