Neurosurgery and Deep Brain Stimulation for Psychiatric Disease: Historical Context and Future Prospects

Growing interest in psychiatric neurosurgery, and in deep brain stimulation (DBS) in particular, requires that the field be placed in the appropriate historical and scientific context. Current methods of neuromodulation for refractory psychiatric conditions are premised on assumptions similar to those proposed in earlier attempts, namely, the number of resistant patients and the absence of any other effective treatments. As a result, a discussion of the current and future prospects, as well as the limits, of neuromodulation is required to avoid a replay of earlier transgressions, and to place its current chapter in the appropriate historical and ethical context.