细胞周期蛋白依赖激酶8
调解人
RNA聚合酶Ⅱ
生物
细胞生物学
抄写(语言学)
细胞周期
转录因子ⅡD
遗传学
RNA聚合酶
核糖核酸
细胞
发起人
基因
信号转导
基因表达
Notch信号通路
语言学
哲学
作者
Zsolt Szilágyi,Claes M. Gustafsson
标识
DOI:10.1016/j.bbagrm.2013.04.010
摘要
Cyclin dependent kinase 8 (Cdk8) is a component of Mediator, an evolutionary conserved multiprotein complex that regulates RNA polymerase II-dependent transcription. Cdk8 has been implicated as a regulator of multiple steps in cell cycle progression. We here discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression.
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