化学
线粒体
聚集诱导发射
荧光
生物物理学
细胞凋亡
荧光寿命成像显微镜
细胞生物学
纳米技术
生物化学
光学
生物
物理
材料科学
作者
Chi Man Leung,Yuning Hong,Sijie Chen,Engui Zhao,Jacky W. Y. Lam,Ben Zhong Tang
摘要
Tracking the dynamics of mitochondrial morphology has attracted much research interest because of its involvement in early stage apoptosis and degenerative conditions. To follow this process, highly specific and photostable fluorescent probes are in demand. Commercially available mitochondria trackers, however, suffer from poor photostability. To overcome this limitation, we have designed and synthesized a fluorescent agent, tetraphenylethene-triphenylphosphonium (TPE-TPP), for mitochondrial imaging. Inherent from the mitochondrial-targeting ability of TPP groups and the aggregation-induced emission (AIE) characteristics of the TPE core, TPE-TPP possesses high specificity to mitochondria, superior photostability, and appreciable tolerance to environmental change, allowing imaging and tracking of the mitochondrial morphological changes in a long period of time.
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