成纤维细胞生长因子受体
成纤维细胞生长因子
成纤维细胞生长因子受体1
成纤维细胞生长因子受体3
受体
生物
受体酪氨酸激酶
成纤维细胞生长因子受体2
遗传学
酪氨酸激酶
细胞生物学
颅缝病
作者
David F. Burke,David Wilkes,Tom L. Blundell,Sue Malcolm
标识
DOI:10.1016/s0968-0004(97)01170-5
摘要
The fibroblast growth factor receptors (FGFRs) are a family of transmembrane tyrosine kinases involved in signalling via interactions with the family of fibroblast growth factors (FGFs). Genetic findings have provided a way of dissecting these interactions. Mutations in three members of the FGFR family have been found in patients with birth defects involving craniosynostosis (premature fusion of the cranial sutures) or skeletal abnormalities. Analyses of the spectrum of mutations found predict that many of them will result in ligand-independent activation of the receptors. Amino acids have also been identified that are likely to be important in determining the specificity of FGFR-FGF interactions.
科研通智能强力驱动
Strongly Powered by AbleSci AI