生物
细胞生物学
线粒体融合
线粒体分裂
形态发生
线粒体
细胞色素c
Bcl-2家族
线粒体凋亡诱导通道
细胞凋亡
线粒体DNA
遗传学
程序性细胞死亡
基因
作者
Arnaud Autret,Seamus J. Martin
出处
期刊:Molecular Cell
[Elsevier]
日期:2009-11-13
卷期号:36 (3): 355-363
被引量:168
标识
DOI:10.1016/j.molcel.2009.10.011
摘要
Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation of mitochondrial fission/fusion dynamics. It has been debated whether the role of Bcl-2 proteins in mitochondrial morphogenesis is functionally distinct from their role in apoptosis, with some arguing that Bax/Bak-induced mitochondrial fission promotes apoptosis-associated cytochrome c release, while others suggest that these functions are separable. Here we review this emerging area and argue for a role for the Bcl-2 family as novel regulators of mitochondrial morphogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI