化学
烷基
非对映体
脱氧尿苷
晶体结构
药物化学
立体化学
盐(化学)
有机化学
DNA
生物化学
作者
J. Bereś,Péter Sándor,Alajos Kàlmán,T. Koritsánszky,László Ötvös
出处
期刊:Tetrahedron
[Elsevier]
日期:1984-01-01
卷期号:40 (12): 2405-2414
被引量:7
标识
DOI:10.1016/0040-4020(84)80024-1
摘要
Some 5-alkyl- and 5-halogeno-2'-deoxyuridine 3',5'-cyclic mono- phosphate P-O-alkyl(aralkyl) esters have been prepared from the silver salts of the parent cyclic monophosphates and alkyl(aralkyl) iodides. The diastereomeric phosphotriesters have been characterized by spectroscopic methods. The crystal and molecular structure of 5-iodo-2'-deoxyuridine 3',5'-cyclic monophosphate P-O-methyl ester with axial methoxy group has been determined. We failed to obtain the desired triesters from the reactions of the cAMP silver salt with alkyl iodides, contrary to previous claims in the literature.
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