医学
抗凝血酶
蛋白质C
蛋白质C缺乏
凝结
蛋白质S
血栓形成
内科学
抗凝血酶Ⅲ缺乏
胃肠病学
纤维蛋白原
血栓性
静脉血栓形成
蛋白质S缺乏症
活化蛋白C抗性
深静脉
凝血病
凝血酶原时间
凝血酶
抗凝剂
血液蛋白质类
血栓调节蛋白
肝素
抗血栓
作者
Etsuji Suehisa,T. Nomura,Tomio Kawasaki,Yuzuru Kanakura
出处
期刊:Blood Coagulation & Fibrinolysis
[Ovid Technologies (Wolters Kluwer)]
日期:2001-03-01
卷期号:12 (2): 95-99
被引量:45
标识
DOI:10.1097/00001721-200103000-00002
摘要
One hundred and thirteen consecutive Japanese patients with deep venous thrombosis (DVT) were studied for the incidences of antithrombin III (AT-III), protein C (PC) and protein S (PS) deficiencies, and the results were compared with those of normal subjects. Ten of the 392 normal Japanese subjects were found with PS deficiency (n = 8, 2.02%) or PC deficiency (n = 2, 0.5%). PS deficiencies comprised type I (1/8, 12.5%), type 11 (4/8, 50%), and type III (3/8, 37.5%). All PC deficiencies were type I. Among patients with DVT, 32 (28.3%) were deficient in AT-III, PC and PS. These patients consisted of two AT-III deficiency (1.77%), nine PC deficiency (7.96%), 20 PS deficiency (17.7%), and one combined deficiency of PC and PS (0.88%). Both of the patients with AT-III deficiency were classified as type II, all those with PC deficiency as type I, and those with PS deficiency as type I in 25% (5/20), type II in 55% (11/20) and type III in 20% (4/20). The frequency of PC and PS deficiencies in patients with DVT were 15.6 and 7.38 times the control population frequency, respectively, and this difference was statistically significant (P < 0.05). These data suggest that the Japanese population has a high frequency of PC and PS deficiencies. We recommend that PS activity should be measured for screening of thrombosis since type II deficiency accounted for approximately 50% of PS deficiency cases in both patients and the normal group in the Japanese.
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