结直肠癌
医学
血小板
癌症
叙述性评论
免疫系统
机制(生物学)
内科学
血小板活化
肿瘤科
大肠癌小鼠模型的建立
病理生理学
免疫学
重症监护医学
认识论
哲学
作者
Charalampos Seretis,Haney Youssef,Mark Chapman
出处
期刊:Platelets
[Informa]
日期:2014-09-05
卷期号:26 (2): 114-118
被引量:45
标识
DOI:10.3109/09537104.2014.894969
摘要
Colorectal cancer, as all solid malignancies, is accompanied by changes in the haemostatic mechanism favoring the establishment of a thrombotic potential, with platelets playing a key-role in this framework; they further link colorectal cancer progression and hypercoagulation with the immune-response against the neoplastic spread. Under this rationale, various studies have assessed the use of platelet indices as prognostic markers of the biological behavior of colorectal cancer, demonstrating significant results. We herein attempt to summarize in a narrative and critical approach the relevant available data and the underlying pathophysiology, stressing the necessity of a more thorough understanding and future implementation of platelet indices in all stages of care we deliver to colorectal cancer patients.
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