细胞生物学
百日咳毒素
生物
少突胶质细胞
溶血磷脂酸
1-磷酸鞘氨醇
受体
信号转导
髓鞘
鞘氨醇
G蛋白
神经科学
生物化学
中枢神经系统
作者
C. Jaillard,Stephen Harrison,Bruno Stankoff,Marie‐Stéphane Aigrot,Andrew R. Calver,G. Duddy,F. S. Walsh,Menelas N. Pangalos,Nariko Arimura,Kozo Kaibuchi,Bernard Zalc,Catherine Lubetzki
标识
DOI:10.1523/jneurosci.4645-04.2005
摘要
Endothelial differentiation gene (Edg) proteins are G-protein-coupled receptors activated by lysophospholipid mediators: sphingosine-1-phosphate (S1P) or lysophosphatidic acid. We show that in the CNS, expression of Edg8/S1P5, a high-affinity S1P receptor, is restricted to oligodendrocytes and expressed throughout development from the immature stages to the mature myelin-forming cell. S1P activation of Edg8/S1P5 on O4-positive pre-oligodendrocytes induced process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway, whereas no retraction was elicited by S1P on these cells derived from Edg8/S1P5-deficient mice. Edg8/S1P5-mediated process retraction was restricted to immature cells and was no longer observed at later developmental stages. In contrast, S1P activation promoted the survival of mature oligodendrocytes but not of pre-oligodendrocytes. The S1P-induced survival of mature oligodendrocytes was mediated through a pertussis toxin-sensitive, Akt-dependent pathway. Our data demonstrate that Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell.
科研通智能强力驱动
Strongly Powered by AbleSci AI