生物
胸腺细胞
祖细胞
T细胞
细胞谱系
T细胞受体
细胞生物学
细胞
祖细胞
电池类型
谱系(遗传)
Cd4 t细胞
CD8型
作者
Maria Ciofani,Juan Carlos Zúñiga-Pflücker
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2010-08-20
卷期号:10 (9): 657-663
被引量:116
摘要
The thymus produces several types of functionally distinct T cell subsets. However, at a more fundamental level only two genetically distinct T cell lineages exist: the γδ and αs T cell lineages. Precisely how these two T cell lineages are generated from common thymocyte progenitor cells remains to be fully elucidated and is under intense investigation. Here, we highlight recent findings that have helped to provide important clues to the mechanisms that underpin the generation of γδ T cells in the mouse thymus.
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