Lung Function and Cognitive Ability in a Longitudinal Birth Cohort Study

肺功能 认知 医学 纵向研究 队列 队列研究 心理学 儿科 发展心理学 内科学 精神科 病理
作者
Marcus Richards,David P. Strachan,Rebecca Hardy,Diana Kuh,Michael Wadsworth
出处
期刊:Psychosomatic Medicine [Lippincott Williams & Wilkins]
卷期号:67 (4): 602-608 被引量:91
标识
DOI:10.1097/01.psy.0000170337.51848.68
摘要

Objective: The objective of this study was to examine the association between forced expiratory volume in 1 second (FEV1) and cognitive ability in midlife in the normal population. Methods: Multiple regression was used to test associations between FEV1 and cognitive function in 1778 men and women in the MRC National Survey of Health and Development, also known as the British 1946 birth cohort. Analyses were adjusted for sex, body size (birth weight, adult height, weight, and chest circumference), socioeconomic status, lifetime smoking, and a range of health indicators, including early respiratory vulnerability (infant lower respiratory infection, childhood asthma, and exposure to atmospheric pollution). Results: FEV1 at 43 years was associated with slower psychomotor speed (peg placement) at the same age and with slower decline in psychomotor speed (letter search speed) from 43 to 53 years, independently of the previously mentioned potential confounders. These independent associations were not observed, however, for adult verbal ability, verbal memory, or rate of decline in memory, which were significantly explained by socioeconomic status and adolescent cognitive ability. In a subsequent analysis, adolescent cognition was positively associated with FEV1, although not with rate of decline in FEV1 from 43 to 53 years, again independently of the previously mentioned confounders. Conclusions: Cognitive function and FEV1 are positively associated across the life course. One possible explanation lies in the parallel action of endocrine, autonomic, and motor control systems on respiration and higher mental function. Because respiration and mental function are both associated with functional capacity and survival, this is a matter of potential clinical significance. AH4 = Alice Heim group abilities test; COPD = chronic obstructive pulmonary disease; FEV1 = forced expiratory volume within 1 second; FVC = forced vital capacity; NSHD = National Survey of Health and Development; NART = National Adult Reading Test; SES = socioeconomic status.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
脑洞疼应助山复尔尔采纳,获得10
刚刚
杨杨杨发布了新的文献求助10
刚刚
3秒前
冷静1等待完成签到 ,获得积分10
3秒前
乐乐应助科研通管家采纳,获得10
8秒前
香蕉觅云应助科研通管家采纳,获得10
8秒前
8秒前
桐桐应助科研通管家采纳,获得10
8秒前
ding应助科研通管家采纳,获得10
8秒前
TGU2331161488应助科研通管家采纳,获得10
8秒前
小二郎应助科研通管家采纳,获得10
8秒前
bkagyin应助科研通管家采纳,获得30
8秒前
烟花应助科研通管家采纳,获得30
8秒前
JamesPei应助科研通管家采纳,获得10
9秒前
zzx发布了新的文献求助30
9秒前
龙阔发布了新的文献求助30
9秒前
zzh完成签到,获得积分10
9秒前
KSung完成签到 ,获得积分10
11秒前
wry完成签到,获得积分10
14秒前
18秒前
zzh发布了新的文献求助20
19秒前
卢艳雨完成签到 ,获得积分10
22秒前
小任吃不胖完成签到,获得积分10
23秒前
NexusExplorer应助ZLY采纳,获得10
26秒前
充电宝应助炙热乌冬面采纳,获得10
30秒前
33秒前
35秒前
在水一方应助mbxjsy采纳,获得10
36秒前
ZLY发布了新的文献求助10
37秒前
龙阔完成签到,获得积分10
37秒前
38秒前
郭郭郭郭完成签到,获得积分10
40秒前
41秒前
直率的小鸭子完成签到,获得积分10
41秒前
上官若男应助奋斗的雅柔采纳,获得10
42秒前
充电宝应助奋斗的雅柔采纳,获得20
42秒前
一一应助李世新采纳,获得10
44秒前
1am33in完成签到 ,获得积分10
44秒前
天天快乐应助yuan采纳,获得10
46秒前
47秒前
高分求助中
Mass producing individuality 600
Разработка метода ускоренного контроля качества электрохромных устройств 500
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
A Combined Chronic Toxicity and Carcinogenicity Study of ε-Polylysine in the Rat 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3824409
求助须知:如何正确求助?哪些是违规求助? 3366708
关于积分的说明 10442228
捐赠科研通 3086016
什么是DOI,文献DOI怎么找? 1697672
邀请新用户注册赠送积分活动 816458
科研通“疑难数据库(出版商)”最低求助积分说明 769640