Ultrasound, PET/CT or temporal artery biopsy for giant cell arteritis? A prospective diagnostic accuracy study (the GAME‐study)

PURPOSE: F]FDG PET/CT) and temporal artery biopsy (TAB) in giant cell arteritis (GCA). METHODS: F]FDG PET/CT and TAB were performed after clinical examination and blood sampling. The main outcome included diagnostic accuracy measures with final clinical expert diagnosis at 6-month follow-up as the comparator. RESULTS: F]FDG PET/CTs and 4 of 90 TABs. CONCLUSION: F]FDG PET/CT combined a high diagnostic accuracy with fewer inconclusive results, suggesting it may be used for second-line testing when ultrasound is inconclusive, reserving TAB for third-line testing. A fast-track setup may facilitate efficient diagnostics.