化学
组织谷氨酰胺转胺酶
壳聚糖
激进的
凝血酶时间
抗氧化剂
嫁接
凝血酶
肽
高分子化学
核化学
生物化学
酶
有机化学
聚合物
部分凝血活酶时间
凝结
免疫学
精神科
血小板
生物
心理学
作者
Wanqing Hu,Meng Li,Xiong Yang,Chang Zhang,Heyi Zhou,Weiguo Xie,Lihong Fan,Min Nie
标识
DOI:10.1016/j.carbpol.2018.09.023
摘要
Free radicals are closely related to the occurrence and development of aging, cancer and inflammation. In this paper, the microbial transglutaminase (MTGase) was used as a catalyst to graft the collagen peptide (COP) molecules on the amino group of carboxymethyl chitosan sulfate (CMCS) to improve the antioxidant effects. FT-IR and NMR spectroscopy were used to confirm the successful grafting of COP to CMCS. Degree of substitution (DS) of CMCS-COP could be controlled by adjusting the reaction conditions. With the increase of concentration, the ability of each sample on scavenging capacity and reducibility tends to increase obviously. The results of anticoagulant experiments showed that the ability of CMCS and CMCS-COP with three different degrees of substitution on activated partial thrombin time (APTT) and prothrombin time (PT) values were all increased to compare with the control group. No relevant cytotoxicity against NIH-3T3 mouse fibroblasts was found for the copolymers. These results suggested that CMCS-COP would appear to be a promising candidate for wound dressing application.
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