吡喹酮
曼氏血吸虫
花生四烯酸
血吸虫病
生物
蠕虫病
驱虫药
医学
免疫学
胃肠病学
药理学
内科学
生理学
蠕虫
兽医学
生物化学
酶
作者
Sahar Selim,Ola El Sagheer,Azza El Amir,Rashida Barakat,Kevin Hadley,Maaike J. Bruins,Rashika El Ridi
出处
期刊:American Journal of Tropical Medicine and Hygiene
[American Society of Tropical Medicine and Hygiene]
日期:2014-11-05
卷期号:91 (5): 973-981
被引量:21
标识
DOI:10.4269/ajtmh.14-0328
摘要
Arachidonic acid (ARA), an omega-6 fatty acid, kills juvenile and adult schistosomes in vitro and displays highly significant and safe therapeutic effects in mice and hamsters infected with Schistosoma mansoni or S. haematobium. This study aims to examine the efficacy and safety of ARA in treatment of school-age children infected with S. mansoni. In total, 66 S. mansoni-infected schoolchildren (20-23 children/study arm) received a single dose of 40 mg/kg praziquantel (PZQ), ARA (10 mg/kg per day for 15 days), or PZQ combined with ARA. The children were examined before and after treatment for worm egg counts in stool and blood biochemical and immunological parameters. ARA proved to be as efficacious as PZQ in treatment of schoolchildren with low infection intensity (78% and 85% cure rates, respectively). For moderate-intensity infection, the ARA and PZQ combination led to 100% cure rate. Biochemical, hematological, and immunological parameters were either unchanged or ameliorated after ARA therapy.
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