The Expression of HIF-1α in Intracerebral Hemorrhage and Its Significance

Objective To investigate the expression of HIF-1αin intracerebral hemorrhage and find out its significance and its correlation with the time of intracerebral hemorrhage.Methods The expression of HIF-1α were assessed by Immunohistochemistry staining.Results In 65 cease of intracerebral hemorrhage positive expression rates of HIF-1α was 61.5%(40/65) and 0 in normal braintissues.The positive rate was significantly higher in intracerebral hemorrhage than in normal brain tissues(P0.05).HIF-1α positive expression rates were 20%(3/15) in 6h,62.5%(20/32) between 6h to 24h and 94.4%(17/18) after 24h of intracerebral hemorrhage.HIF-1α expression was closely related with time of operation after intracerebral hemorrhage(P0.05).Conclusion HIF-1α was over expressed in intracerebral hemorrhage,and there is a significant correlation with the time after intracerebral hemorrhage.It can help hypoxic neurons survive in the condition of hypoxia.