OBJECTIVE:To introduce pharmacogenomics and its applications in establishing clinical pharmacotherapeutic schemes.METHODS:Based on the analysis of the related literatures,the development and contents of pharmacogenomics and their relationship with individualized medication were summarized.RESULTS:Pharmacogenomics studies the association between gene polymorphisms and the variance of drug effects.CONCLUSION:Pharmacogenomics provides a theoretical basis for medication with safety,effectiveness and rationality.