细胞周期蛋白B1
生物
细胞周期蛋白B
细胞生物学
细胞周期蛋白
细胞周期蛋白依赖激酶1
有丝分裂
DNA损伤
细胞周期蛋白A2
细胞周期蛋白D
G2-M DNA损伤检查点
细胞周期
细胞周期蛋白
细胞周期检查点
周期素
核分裂突变
衰老
DNA
遗传学
细胞
作者
Yuji Nakayama,Naoto Yamaguchi
标识
DOI:10.1016/b978-0-12-407695-2.00007-x
摘要
The cyclin B1–Cdk1 complex is a key regulator of mitotic entry. A large number of proteins are phosphorylated by the cyclin B1–Cdk1 complex prior to mitotic entry. Regulation of the mitotic events is linked to the control of the activity of the cyclin B1–Cdk1 complex to make cells enter mitosis, arrest at G2-phase, or skip mitosis. The roles of cyclin B1 levels in DNA damage are described. The ATM/ATR pathway acts as a molecular switch for regulating cell fates, flipping between cell death via progress into mitosis and polyploidization via sustained G2 arrest upon DNA damage, where cyclin B1 degradation is important for inducing polyploidization. The decrease in cyclin B1 levels that is induced by DNA damage leads to polyploidization in DNA damage-induced senescence. A useful method for monitoring the expression level of cyclin B1 throughout cell cycle progression in living cells is also presented.
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