Correlation of AST/ALT ratio and hepatic cirrhosis

Objective To determine the AST/ALT ratio in healthy control,chronic hepatitis (G 0～3) and hepatic cirrhosis, and evaluate the relationship of AST/ALT ratio and hepatic cirrhosis. Method The levels of AST and ALT of healthy control group, patients with chronic hepatitis (G 0～3) and patients with hepatic cirrhosis were determined by Olympus AU640 automatic biochemical analyzer. Results There was no statistically significance difference between the AST/ALT ratios of healthy control group and patients with chronic hepatitis of different phases (G 0～3,P0.05), but there was statistically significance diference between healthy control group and patients with hepatic cirrhosis(P0.01). The difference was increasing with the increase in the class of Child-Pugh classification (P0.01).Correlation analysis demonstrated that the AST/ALT ratio of patients with hepatic cirrhosis has positive correlation with the child-Pugh integral (r=0.656,P0.01). There was statistically significance between the AST/ALT ratios of patients with chronic hepatitis (G 0～3) and patients with hepatic cirrhosis (P0.01). There was statistically significance difference between AST/ALT ratios of living and dead patients with hepatic cirrhosis (P0.05). There was statistically significance difference between AST/ALT ratios of hepatic cirrhosis patients with and without upper gastrointestinal bleeding (P0.05). Conclusion The AST/ALT ratios of patients with hepatic cirrhosis can be used as a indicator of the condition of patients with hepatic cirrhosis, and for prognosis judgement.