Objective To discuss the effect of somatostatin on treatment of acute pancreatitis. Methods A total of 103 cases of acute pancreatitis were divided into two groups A and B. The group A (n=56) was AEP and the group B(n=47) was SAP. The two groups were sub-divided into somatostatin treatment group and control group. Contrast analysis was made between two groups on the mortality, death reason, hospital stay, pancreatic cyst, pancreatic abscess, pancreatic fistula, bowel fistula and intraabdominal hemorrhage. Results The complication rate of somatostatin treatment group was not obviously less than that of control group. The mortality of acute pancreatitis was obviously lower in the somatostatin treatment group than that in the control group. Conclusion The treatment value of the somatostatin in acute pancreatitis especially in severe acute pancreatitis needs further studies.