Macroporous crosslinking poly(2-hydroxyethyl methacrylate) (PHEMA) resins were prepared by suspension polymerization. The adsorption properties of PHEMA for bilirubin were studied. The results showed that, the adsorption percentage was affected by pore distribution of resins, adsorption temperature, ion strength and the presence of albumin. PHEMA resins showed good adsorption properties for bilirubin, and PHEMA resin immobilizing ethanolamine had better adsorption capacity.