Effect of carvedilol on treatment and prognosis in patients with ischemic cardiomyopathy Complicated atria fibrillation

Objective To observe effects of carvedilol on the changes of B-type natriuretic peptide(BNP) concentration in ischemic cardiomyopathy(ICM)patients and on fhe prognosis of these patients.Methods 86 patients admitted for ischemic cardiomyopathy with atria fibrillation and BNP concentration before and after treatment were followed.The subjects were divided into two groups based on with or without carvedilol.Carvedilol group included 44 cases,another group included 42 cases.Endpoints was death or 6 month readmission.Results BNP levels decreased more in cardevilol group(P0.05);there were 5 endpoint events in carvedilol group(11.4 %),20 endpoint events in another group(47.6 %),the ratio of endpoint events was significant different in two groups(P 0.01).BNP level of endpoint events was over 700 pg/ml.Conclusion Carvedilol can decrease BNP level and improve prognosis in patients with chronic heart failure,patients admitted for ischemic cardiomyopathy,after treatment BNP level700pg/ml can predict prognosis.