Objective To investigate the efficacy of time treatment on peripheral facial paralysis and sift out the best protocol for time acupuncture-moxibustion treatment for peripheral facial paralysis. Methods Central randomization was performed. Two hundred patients meeting the inclusion criteria were randomly allocated to group A, B, C, D and E group. A received time acupuncture; group B, time acupuncture plus moxibustion; group C, time electroacupuncture; group D, time acupuncture plus muscle-region alignment needling; group E, non-time acupuncture. Results There was no statistically significant difference in the total efficacy rate between different groups (P0.05). Conclusion The clinical samples need to be increased. Time treatment for peripheral facial paralysis is worthy of discussion.