A retrospective analysis of 108 cases with drug-induced liver injury

【Objective】 To summarize drug-induced liver diseases in the treatment of 108 cases of tuberculosis in our institute from September 2004 to August 2009 by analyzing the clinical features in order to find the best treatment.【Methods】Tuberculosis patients with no clinical symptoms of drug-induced liver disease whose ALT level was under 150 units continued to receive anti-tuberculosis treatment and simultaneous liver protection and en-zyme control drugs and their liver function was monitored closely.Tuberculosis patients with serious drug-induced liver disease whose ALT level was over 150 units were treated with hepatic drugs first rather than anti-tuberculosis drugs until their liver function recovered according to monitored data.【Result】108 cases of tuberculoses patients are cured.【Conclusion】Serious liver damage can be caused by anti-tuberculosis drugs,which should be diagnosed and treated early.Patients with no clear drug-induced liver damage can be treated with anti-tuberculosis drugs to ensure the effectiveness of treatment.